We compared two methods for measuring large optical frequency differences: an optical frequency comb generator, which creates a large number of sidebands from a single-mode laser through electro-optic modulation, and an optical frequency interval divider chain, which divides a frequency gap successively by two until it becomes accessible to a radio-frequency counter. By locking two diode lasers to two modulation sidebands of a comb generator, ~1 THz apart, and measuring this interval with a chain of four phase-locked interval dividers, we demonstrate for the first time to our knowledge the accuracy of both techniques within an experimental limit of 6.8 x 10(-15).