Pyrazolopyridines with potent activity against herpesviruses: effects of C5 substituents on antiviral activity

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1157-61. doi: 10.1016/j.bmcl.2007.11.120. Epub 2007 Dec 4.

Abstract

Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo[1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described.

MeSH terms

  • Acyclovir / pharmacology*
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Combinatorial Chemistry Techniques
  • Herpesviridae / drug effects*
  • Humans
  • Molecular Structure
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Pyridines / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Pyrazoles
  • Pyridines
  • pyrazolopyridine
  • Acyclovir