Splenic infarction due to concomitant hereditary spherocytosis and sickle cell trait

Robin Yates Dulman; George R Buchanan; Howard Ginsburg; Nancy R Fefferman; M Alba Greco; Dariusz Borys; Francine Blei

doi:10.1016/j.jpedsurg.2007.07.057

Splenic infarction due to concomitant hereditary spherocytosis and sickle cell trait

J Pediatr Surg. 2007 Dec;42(12):2129-31. doi: 10.1016/j.jpedsurg.2007.07.057.

Authors

Robin Yates Dulman¹, George R Buchanan, Howard Ginsburg, Nancy R Fefferman, M Alba Greco, Dariusz Borys, Francine Blei

Affiliation

¹ Department of Pediatric Hematology/Oncology, NYU School of Medicine, New York, NY 10016, USA. yatesr01@med.nyu.edu

PMID: 18082724
DOI: 10.1016/j.jpedsurg.2007.07.057

Abstract

Concomitant hereditary spherocytosis and sickle cell trait, although extremely rare, could potentially lead to splenic sequestration or infarction. We report here the first case of splenic infarction in a child with hereditary spherocytosis and sickle cell trait while flying on a commercial aircraft. The presence of hypoxia, hemoconcentrated erythrocytes, and sickle hemoglobin created the perfect environment for clinical sequelae.

Publication types

Case Reports

MeSH terms

Biopsy, Needle
Child
Female
Follow-Up Studies
Humans
Immunohistochemistry
Risk Assessment
Severity of Illness Index
Sickle Cell Trait / complications*
Sickle Cell Trait / diagnosis
Spherocytosis, Hereditary / complications*
Spherocytosis, Hereditary / diagnosis
Splenectomy / methods
Splenic Infarction / etiology*
Splenic Infarction / pathology
Splenic Infarction / surgery*
Tomography, X-Ray Computed
Treatment Outcome