Heterogeneity of hemolysin expression during neonatal Streptococcus agalactiae sepsis

J Clin Microbiol. 2008 Feb;46(2):807-9. doi: 10.1128/JCM.01963-07. Epub 2007 Dec 12.

Abstract

The beta-hemolysin of Streptococcus agalactiae is a major virulence factor; consequently, nonhemolytic strains rarely cause infections. We report on a case of neonatal sepsis caused by a strain displaying heterogeneous hemolysin expression. It was detected by the simultaneous isolation of hemolytic and nonhemolytic colonies from cultures of the infant's blood.

Publication types

  • Case Reports

MeSH terms

  • ATP-Binding Cassette Transporters / genetics
  • Antigens, Bacterial / analysis
  • Bacterial Proteins / analysis
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Bacterial Typing Techniques
  • DNA Transposable Elements
  • DNA, Bacterial
  • Genotype
  • Hemolysin Proteins / biosynthesis*
  • Hemolysin Proteins / genetics
  • Hemolysis / genetics
  • Hemolysis / physiology*
  • Humans
  • Infant, Newborn
  • Membrane Proteins / analysis
  • Polymerase Chain Reaction
  • Sepsis / microbiology*
  • Serotyping
  • Streptococcal Infections / microbiology*
  • Streptococcus agalactiae / isolation & purification*
  • Streptococcus agalactiae / physiology*

Substances

  • ATP-Binding Cassette Transporters
  • Antigens, Bacterial
  • Bacterial Proteins
  • DNA Transposable Elements
  • DNA, Bacterial
  • Hemolysin Proteins
  • Membrane Proteins
  • Rib protein, Streptococcus agalactiae