Zinc for diarrhoea management in Sub-Saharan Africa: a review

East Afr Med J. 2007 Sep;84(9):441-9. doi: 10.4314/eamj.v84i9.9554.

Abstract

Objectives: To review the evidence supporting the inclusion of zinc for diarrhoea management specifically in sub-Saharan Africa where diarrhoea remains a leading cause of morbidity and mortality.

Data sources: We searched PubMed for studies assessing the efficacy and effectiveness of zinc for the treatment and prevention of common childhood morbidities.

Study selection: We included only studies conducted in sub-Saharan Africa.

Data synthesis: Details of studies conducted in sub-Saharan Africa are presented in the context of the global evidence supporting the use of zinc for diarrhoea management.

Conclusions: There is a significant body of evidence to support the use of zinc for diarrhoea management in sub-Saharan Africa. The accelerated introduction of zinc into routine community-based diarrhoea treatment is critical for the reduction of diarrhoea morbidity and mortality.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Age Factors
  • Child Welfare
  • Child, Preschool
  • Diarrhea / drug therapy*
  • Diarrhea / epidemiology
  • Diarrhea / mortality
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Trace Elements / deficiency
  • Trace Elements / therapeutic use
  • Treatment Outcome*
  • Zinc / deficiency
  • Zinc / therapeutic use*

Substances

  • Trace Elements
  • Zinc