Purification and characterization of xylanase from Aspergillus ficuum AF-98

Bioresour Technol. 2008 Sep;99(13):5938-41. doi: 10.1016/j.biortech.2007.10.051. Epub 2008 Feb 20.

Abstract

The purification and characterization of xylanase from Aspergillus ficuum AF-98 were investigated in this work. The extracellular xylanase from this fungal was purified 32.6-fold to homogeneity throughout the precipitation with 50-80% (NH(4))(2)SO(4), DEAE-Sephadex A-50 ion exchange chromatography and Sephadex G-100 chromatography. The purified xylanase (specific activity at 288.7 U/ mg protein) was a monomeric protein with a molecular mass of 35.0 kDa as determined by SDS-PAGE. The optimal temperature and pH for the action of the enzyme were at 45 degrees C and 5.0, respectively. The xylanase was activated by Cu(2+) up to 115.8% of activity, and was strongly inhibited by Hg(2+), Pb(2+) up to 52.8% and 89%, respectively. The xylanase exhibited K(m) and V(max) values of 3.267 mg/mL, 18.38 M/min/mg for beechwood xylan and 3.747 mg/mL, 11.1M/min/mg for birchwood xylan, respectively.

MeSH terms

  • Aspergillus / enzymology*
  • Chromatography, Gel
  • Chromatography, Ion Exchange
  • Endo-1,4-beta Xylanases / isolation & purification
  • Endo-1,4-beta Xylanases / metabolism*
  • Fungal Proteins / isolation & purification
  • Fungal Proteins / metabolism
  • Hydrogen-Ion Concentration
  • Molecular Weight
  • Thermodynamics
  • Wood
  • Xylans / isolation & purification
  • Xylans / metabolism

Substances

  • Fungal Proteins
  • Xylans
  • Endo-1,4-beta Xylanases