NUP98-NSD1 fusion by insertion in acute myeloblastic leukemia

Cancer Genet Cytogenet. 2008 Jan 1;180(1):43-6. doi: 10.1016/j.cancergencyto.2007.09.007.

Abstract

A case of NUP98-NSD1 gene fusion resulting from the insertion of a subtelomeric part of chromosome 11p15.4 within the subtelomeric part of 5q35 was detected in a child with acute myeloblastic leukemia. This new case illustrates the importance of using fluorescence in situ hybridization followed by reverse transcriptase-polymerase chain reaction techniques to detect abnormalities involving subtelomeric chromosomal regions.

Publication types

  • Case Reports

MeSH terms

  • Base Sequence
  • Child, Preschool
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 5*
  • Gene Fusion*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Molecular Sequence Data
  • Oncogene Proteins, Fusion / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic*

Substances

  • NUP98-NSD1 protein, human
  • Oncogene Proteins, Fusion