Revisited 3'-deoxy-3'-C-methyl-beta-D-ribonucleoside series

Mohamed Aljarah; Sarah Couturier; Gilles Gosselin; Christophe Mathé; Christian Périgaud

doi:10.1080/15257770701521730

Revisited 3'-deoxy-3'-C-methyl-beta-D-ribonucleoside series

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1125-8. doi: 10.1080/15257770701521730.

Authors

Mohamed Aljarah¹, Sarah Couturier, Gilles Gosselin, Christophe Mathé, Christian Périgaud

Affiliation

¹ UMR 5625 CNRS-UM II, Université Montpellier II, Montpellier, France.

PMID: 18058550
DOI: 10.1080/15257770701521730

Abstract

The synthesis of some 3'-deoxy-3'-C-methylnucleoside analogues bearing naturally occuring nucleic acid bases was achieved from the preparation of a suitable peracylated 3-deoxy-3-C-methyl sugar using a stereoselective pathway. In addition, examples of chemical modifications at the 2' position are presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry
Deoxyribonucleosides / chemical synthesis*
Deoxyribonucleosides / chemistry*
Drug Design
Glycosylation
Methylation
Stereoisomerism

Substances

Antiviral Agents
Deoxyribonucleosides