ODN-based drugs for targeting of extracellular proteins

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1047-50. doi: 10.1080/15257770701509602.

Abstract

In this work a novel approach to identify new therapeutic targets consisting of serum proteins which contain an oligonucleotide binding domain is presented.

MeSH terms

  • Binding Sites
  • Blood Proteins / antagonists & inhibitors
  • Blood Proteins / chemistry
  • Blood Proteins / genetics*
  • Drug Design
  • Gene Targeting
  • HMGB1 Protein / antagonists & inhibitors
  • HMGB1 Protein / chemistry
  • HMGB1 Protein / genetics
  • Humans
  • Macromolecular Substances
  • Models, Molecular
  • Oligodeoxyribonucleotides / chemistry
  • Oligodeoxyribonucleotides / genetics*
  • Oligodeoxyribonucleotides / pharmacology*

Substances

  • Blood Proteins
  • HMGB1 Protein
  • Macromolecular Substances
  • Oligodeoxyribonucleotides