Aldehydic oligonucleotide: a key intermediate for the preparation of oligonucleotide conjugates through oxime bond formation

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):883-7. doi: 10.1080/15257770701505436.

Abstract

Oligonucleotides functionalized with an aldehyde group are the key intermediates used for the preparation of peptide-oligonucleotide conjugates through the formation of an oxime linkage. Herein, we describe a brief overview of various synthetic protocols developed in our laboratory for the preparation of aldehyde containing oligonucleotides and their subsequent conjugation with peptides.

MeSH terms

  • Aldehydes / chemistry
  • Drug Design
  • Molecular Structure
  • Oligodeoxyribonucleotides / chemical synthesis*
  • Oligodeoxyribonucleotides / chemistry*
  • Oximes / chemistry
  • Peptide Nucleic Acids / chemical synthesis*
  • Peptide Nucleic Acids / chemistry*
  • Peptides / chemistry

Substances

  • Aldehydes
  • Oligodeoxyribonucleotides
  • Oximes
  • Peptide Nucleic Acids
  • Peptides