Functional oncocytic adrenocortical carcinoma

Endocr Pathol. 2007 Fall;18(3):187-9. doi: 10.1007/s12022-007-9000-4.

Abstract

We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Cortex Neoplasms / diagnosis*
  • Adrenal Cortex Neoplasms / metabolism
  • Adrenal Cortex Neoplasms / physiopathology*
  • Adrenocortical Carcinoma / diagnosis*
  • Adrenocortical Carcinoma / metabolism
  • Adrenocortical Carcinoma / physiopathology*
  • Adult
  • Aldosterone / metabolism
  • Humans
  • Hydrocortisone / metabolism
  • Male
  • Oxyphil Cells / pathology

Substances

  • Aldosterone
  • Hydrocortisone