Successful unrelated cord blood transplantation for a patient with CD40 ligand deficiency

Haematologica. 2007 Dec;92(12):1727-8. doi: 10.3324/haematol.11531.

Abstract

We report a CD40 ligand deficiency (CD40LD) patient who was successfully treated with unrelated cord blood transplantation (URCBT). Conditioning regimen was busulfan and cyclophosphamide. The clinical course was uneventful and durable engraftment was achieved. This successful case encourages the use of URCB as an alternative donor source for CD40LD patients.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / genetics
  • Agammaglobulinemia / therapy*
  • Busulfan / administration & dosage
  • CD40 Antigens / deficiency*
  • Cord Blood Stem Cell Transplantation*
  • Cyclophosphamide / administration & dosage
  • Genetic Diseases, Inborn / genetics
  • Genetic Diseases, Inborn / therapy*
  • Graft Survival
  • Humans
  • Infant
  • Living Donors*
  • Male
  • Neutropenia / genetics
  • Neutropenia / therapy*
  • Transplantation Conditioning*

Substances

  • CD40 Antigens
  • Cyclophosphamide
  • Busulfan