Synthesis of (+/-)-N-2-methylpropyl-N-1'-methylacetonyl-nitrosamine

Chin Med Sci J. 1991 Jun;6(2):119-21.

Abstract

N-2-methylpropyl-N-1-methylacetonyl-nitrosamine (NMAMPA), first isolated from moldy and normal foods, was synthesized by chemical means. The structure and molecular weight of the synthetic NMAMPA were elucidated by spectrometry. A combination of spectral and chromatographic data indicated that the synthetic NMAMPA is identical to that obtained naturally. Synthetic NMAMPA is a racemic modification, and a carcinogen which can induce esophageal and forestomach cancer in rats.

MeSH terms

  • Carcinogens / chemical synthesis*
  • Carcinogens / chemistry
  • Nitrosamines / chemical synthesis*
  • Nitrosamines / chemistry
  • Stereoisomerism

Substances

  • Carcinogens
  • Nitrosamines
  • N-2-methylpropyl-N-1-methylacetonylnitrosamine