Abstract
Neuropathologies that affect our population include ischemic stroke and neurodegenerative diseases of immune origin, including multiple sclerosis. The endocannabinoid system in the brain, including agonists anandamide (arachidonyl ethanolamide) and 2-arachidonoylglycerol, and the CB1 and CB2 cannabinoid receptors, has been implicated in the pathophysiology of these disease states, and can be a target for therapeutic interventions. This review concentrates on cellular signal transduction pathways believed to be involved in the cellular damage.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain / metabolism
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Brain / pathology
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Brain Diseases / metabolism*
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Brain Diseases / pathology
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Cannabinoid Receptor Modulators / metabolism*
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Endocannabinoids*
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Humans
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Reactive Nitrogen Species / metabolism*
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Reactive Oxygen Species / metabolism*
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Receptors, Cannabinoid / metabolism
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Signal Transduction / physiology*
Substances
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Reactive Nitrogen Species
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Reactive Oxygen Species
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Receptors, Cannabinoid