Abstract
Fagaronine derivatives syntheses were optimized and their effect on PC3 androgen-independent prostate cell line was evaluated. An assessment of the lipophilicity of the benzo[c]phenanthridine derivatives was achieved at pH 7.4 and et 6.7 by determining log D.
MeSH terms
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Adenocarcinoma / drug therapy*
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Alkaloids / chemistry*
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Alkaloids / therapeutic use
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Androgens / metabolism*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Benzophenanthridines
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Drug Resistance, Neoplasm / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Hydrogen-Ion Concentration / drug effects
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Male
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Molecular Structure
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Phenanthridines / chemical synthesis
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Phenanthridines / chemistry*
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Phenanthridines / pharmacology
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Phenanthridines / therapeutic use
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Prostatic Neoplasms / drug therapy*
Substances
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Alkaloids
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Androgens
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Antineoplastic Agents
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Benzophenanthridines
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Phenanthridines
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fagaronine