Abstract
The protozoan, Toxoplasma gondii, is a natural pathogen of mouse and a zoonosis of man. Immunity against the pathogen is largely mediated by interferon-stimulated cell-autonomous mechanisms that are strikingly different between man and mouse. There are many poorly understood host and pathogen variables that affect the outcome of infection.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Fibroblasts / immunology
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Fibroblasts / parasitology
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Host-Pathogen Interactions*
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Humans
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Immunity, Innate*
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Interferons / pharmacology*
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L Cells
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Macrophages / immunology
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Macrophages / parasitology
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Mice
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Mice, Inbred C3H
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Mice, Inbred C57BL
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Species Specificity
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Toxoplasma / pathogenicity*
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Toxoplasma / physiology
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Toxoplasmosis / immunology*
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Toxoplasmosis / parasitology
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Toxoplasmosis, Animal / immunology*
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Toxoplasmosis, Animal / parasitology