Diet with LPP for renal patients increases daily energy expenditure and improves motor function in parkinsonian patients with motor fluctuations

Nutr Neurosci. 2007 Jun-Aug;10(3-4):129-35. doi: 10.1080/10284150701414046.

Abstract

Objective: To establish whether a diet based on the usage of low-protein products for renal patients (LPP) is associated with higher energy expenditure (EE) than a free low-protein diet (NO-LPP) by calculating 24 h EE by indirect calorimetry using an electronic armband monitor.

Design: Randomized, cross-over, single-blind, pilot clinical trial performed comparing two different low-protein dietary regimens.

Subjects: Forty-two days with LPP and 42 days with NO-LPP regimen in six patients with Parkinson's disease with levodopa.

Methods: Monitoring patient response to two different nutritional schemes through indirect calorimetry (armband), BMI, Patient Global Improvement Scale.

Results: Mean total EE was 1731 +/- 265 kcal/day with NO-LPP vs. 1903 +/- 265 kcal/day with LPP (p = 0.02).

Conclusions: The usage of LPP increases EE and improves motor function in PD patients to a greater extent than NO-LPP dietary regimen. Calorie intake should be increased to prevent malnutrition in the long-term.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Calorimetry
  • Cross-Over Studies
  • Diet, Protein-Restricted*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Activity / physiology*
  • Parkinson Disease / diet therapy*
  • Parkinson Disease / physiopathology*
  • Pilot Projects
  • Renal Insufficiency / diet therapy*
  • Renal Insufficiency / physiopathology
  • Single-Blind Method