Spirastrellolides C to G: macrolides obtained from the marine sponge Spirastrella coccinea

David E Williams; Robert A Keyzers; Kaoru Warabi; Kelsey Desjardine; Jenna L Riffell; Michel Roberge; Raymond J Andersen

doi:10.1021/jo7018174

Spirastrellolides C to G: macrolides obtained from the marine sponge Spirastrella coccinea

J Org Chem. 2007 Dec 7;72(25):9842-5. doi: 10.1021/jo7018174. Epub 2007 Nov 8.

Authors

David E Williams¹, Robert A Keyzers, Kaoru Warabi, Kelsey Desjardine, Jenna L Riffell, Michel Roberge, Raymond J Andersen

Affiliation

¹ Departments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, B.C., Canada V6T 1Z1.

PMID: 17988148
DOI: 10.1021/jo7018174

Abstract

Five new macrolides, spirastrellolides C (3) to G (7), have been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Their structures have been elucidated by a combination of spectroscopic analysis and chemical transformations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / isolation & purification
Macrolides / chemistry*
Macrolides / isolation & purification
Magnetic Resonance Spectroscopy / methods
Magnetic Resonance Spectroscopy / standards
Molecular Conformation
Porifera / chemistry*
Reference Standards
Stereoisomerism

Substances

Enzyme Inhibitors
Macrolides
spirastrellolide C
spirastrellolide G