Serotonin-1A receptors in frontotemporal dementia compared with controls

Krista L Lanctôt; Nathan Herrmann; Hooman Ganjavi; Sandra E Black; Pablo M Rusjan; Sylvain Houle; Alan A Wilson

doi:10.1016/j.pscychresns.2007.07.003

Serotonin-1A receptors in frontotemporal dementia compared with controls

Psychiatry Res. 2007 Dec 15;156(3):247-50. doi: 10.1016/j.pscychresns.2007.07.003. Epub 2007 Oct 31.

Authors

Krista L Lanctôt¹, Nathan Herrmann, Hooman Ganjavi, Sandra E Black, Pablo M Rusjan, Sylvain Houle, Alan A Wilson

Affiliation

¹ Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. krista.lanctot@sunnybrook.ca

PMID: 17976961
DOI: 10.1016/j.pscychresns.2007.07.003

Abstract

Using PET neuroimaging, we demonstrated that four frontotemporal lobar dementia (FTLD) patients had significantly decreased serotonin 5-HT(1A) binding potential (BP) compared with controls in all 10 brain regions examined. These pilot data suggest that profound 5-HT(1A) BP losses may be present and contribute to symptomatology and treatment response in FTLD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Binding Sites
Dementia / metabolism*
Female
Humans
Male
Middle Aged
Pilot Projects
Positron-Emission Tomography
Receptor, Serotonin, 5-HT1A / metabolism*

Substances

Receptor, Serotonin, 5-HT1A