Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)

J Med Chem. 2007 Nov 29;50(24):5890-3. doi: 10.1021/jm7010595. Epub 2007 Oct 31.

Abstract

A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability
  • Carbamates / chemical synthesis*
  • Carbamates / pharmacokinetics
  • Carbamates / pharmacology
  • Dogs
  • Esters
  • Growth Hormone / blood
  • Growth Hormone / metabolism*
  • Human Growth Hormone / metabolism
  • Humans
  • Macaca fascicularis
  • Rats
  • Solubility
  • Structure-Activity Relationship
  • Tetrazoles / chemical synthesis*
  • Tetrazoles / pharmacokinetics
  • Tetrazoles / pharmacology
  • Water

Substances

  • 4-(hydroxybutyl)carbamic acid 2-(5-(1-(2-amino-2-methylpropionylamino)-2-benzyloxyethyl)tetrazol-1-yl)ethyl ester
  • Carbamates
  • Esters
  • Tetrazoles
  • Water
  • Human Growth Hormone
  • Growth Hormone