Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses

Biotechnol Lett. 2008 Mar;30(3):475-9. doi: 10.1007/s10529-007-9565-5. Epub 2007 Oct 31.

Abstract

Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology
  • Cell Line
  • Drug Resistance, Viral
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Influenza A virus / drug effects*
  • Oseltamivir / pharmacology*
  • Polyethyleneimine / analogs & derivatives*
  • Polyethyleneimine / pharmacology
  • Zanamivir / pharmacology*

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • N,N-dodecyl,methyl-polyethylenimine
  • Oseltamivir
  • Polyethyleneimine
  • Zanamivir