Cathepsin D inhibitor from potato reverses inhibition of collagen biosynthesis in wounded skin of rats with experimental diabetes

Acta Biochim Pol. 1991;38(1):115-8.

Abstract

It was found that streptozotocin-induced diabetes is accompanied by increased proteolytic activity and decreased collagen biosynthesis in rat skin wounds. External application of cathepsin D inhibitor from potatoes normalized the proteolytic activity and restored collagen biosynthesis in wounded skin of these animals.

MeSH terms

  • Animals
  • Cathepsin D / antagonists & inhibitors*
  • Collagen / biosynthesis*
  • Diabetes Mellitus, Experimental / metabolism*
  • Male
  • Pepstatins / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Skin / enzymology
  • Skin / injuries
  • Skin / metabolism*
  • Solanum tuberosum / chemistry*
  • Solanum tuberosum / enzymology

Substances

  • Pepstatins
  • Streptomyces pepsin inhibitor
  • Collagen
  • Cathepsin D
  • pepstatin