Abstract
It was found that streptozotocin-induced diabetes is accompanied by increased proteolytic activity and decreased collagen biosynthesis in rat skin wounds. External application of cathepsin D inhibitor from potatoes normalized the proteolytic activity and restored collagen biosynthesis in wounded skin of these animals.
MeSH terms
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Animals
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Cathepsin D / antagonists & inhibitors*
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Collagen / biosynthesis*
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Diabetes Mellitus, Experimental / metabolism*
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Male
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Pepstatins / pharmacology*
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Rats
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Rats, Inbred Strains
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Skin / enzymology
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Skin / injuries
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Skin / metabolism*
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Solanum tuberosum / chemistry*
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Solanum tuberosum / enzymology
Substances
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Pepstatins
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Streptomyces pepsin inhibitor
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Collagen
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Cathepsin D
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pepstatin