Pyrene modification leads to increased catalytic activity in minimal hammerhead ribozymes

Chem Commun (Camb). 2007 Nov 14:(42):4357-9. doi: 10.1039/b711170c. Epub 2007 Aug 14.

Abstract

Highly active variants of minimal hammerhead ribozymes are generated by the replacement of substantial parts of stem-loop structures with pyrene building blocks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Nucleic Acid Conformation
  • Protein Conformation
  • Pyrenes / chemistry*
  • RNA / chemistry
  • RNA, Catalytic / chemistry*

Substances

  • Pyrenes
  • RNA, Catalytic
  • hammerhead ribozyme
  • RNA