Quantification and detectability of in-stent stenosis with CT angiography and MR angiography in arterial stents in vitro

AJR Am J Roentgenol. 2007 Nov;189(5):1238-42. doi: 10.2214/AJR.07.2501.

Abstract

Objective: The purpose of this study was to compare CT angiography (CTA) and MR angiography (MRA) for the detectability of 75% and 95% stenoses in phantoms using six different stents.

Materials and methods: Six different stents (Expander, Hemobahn, SelfX, Smart, Symphony, and Wallstent) were inserted into tubes filled with contrast agent (ioversol or gadoteric acid). To mimic stenoses of 75% and 95% of the patent lumen, 8-mm-diameter nylon cylinders were bored in the central axis (2 mm and 4 mm, respectively) and placed into the stent lumen. Intensity profiles across stenoses on 2-mm coronal reformatted sections of CTA or MRA were compared, and the detectability of the residual lumen was assessed using a subjective score.

Results: CTA showed relative in-stent signal attenuation for the in-stent stenoses of the tested stents ranging from 75% to 100% of the signal intensity of the control. SelfX and Symphony showed further shading of the residual lumen due to beam-hardening artifacts. Overestimation of stenosis was associated with low-grade stenoses in which the border of the lumen was closer to the stent struts. MRA showed relative in-stent signal attenuation of the in-stent stenoses ranging from 30% to 100% of the signal intensity of the control. Strut thickness tended to correlate with higher attenuation at CT.

Conclusion: CTA may be more suitable for differentiation between 95% stenosis and occlusion; MRA has higher sensitivity in detecting 75% stenoses. Strut thickness and mesh size did not prove to be significant predictors for signal attenuation or overall image quality.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Angiography / instrumentation
  • Angiography / methods*
  • Blood Vessel Prosthesis / adverse effects*
  • Graft Occlusion, Vascular / diagnosis*
  • Graft Occlusion, Vascular / etiology*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Angiography / instrumentation
  • Magnetic Resonance Angiography / methods
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Stents / adverse effects*
  • Tomography, X-Ray Computed / instrumentation
  • Tomography, X-Ray Computed / methods*