Primary cutaneous CD30+ anaplastic large-cell lymphomas mimicking keratoacanthomas

Clin Exp Dermatol. 2007 Nov;32(6):668-71. doi: 10.1111/j.1365-2230.2007.02477.x.

Abstract

Primary cutaneous anaplastic large cell lymphoma (ALCL) may be associated with keratoacanthoma (KA)-like epithelial hyperplasia and dense eosinophilic and neutrophilic infiltrates. Diagnosis in such cases is challenging both clinically and histologically, because the large atypical lymphoid cells may be obscured by the massive infiltrate of eosinophils and neutrophils, or confused with invasive squamous cell carcinoma or KA. We recently encountered two cases of CD30+ ALCL presenting with a KA-like tumour on the eyelid and nose, respectively. One showed features of KA histologically, with marked tissue eosinophilia and neutrophilia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Eyelid Neoplasms / diagnosis
  • Eyelid Neoplasms / pathology
  • Facial Neoplasms / diagnosis*
  • Facial Neoplasms / pathology
  • Female
  • Humans
  • Keratoacanthoma / diagnosis*
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / diagnosis*
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / pathology
  • Male
  • Middle Aged
  • Nose Neoplasms / diagnosis
  • Nose Neoplasms / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology