Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids

Bhahwal A Shah; Ajay Kumar; Pankaj Gupta; Madhunika Sharma; Vijay K Sethi; Ajit K Saxena; Jaswant Singh; Ghulam N Qazi; Subhash C Taneja

doi:10.1016/j.bmcl.2007.10.011

Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6411-6. doi: 10.1016/j.bmcl.2007.10.011. Epub 2007 Oct 10.

Authors

Bhahwal A Shah¹, Ajay Kumar, Pankaj Gupta, Madhunika Sharma, Vijay K Sethi, Ajit K Saxena, Jaswant Singh, Ghulam N Qazi, Subhash C Taneja

Affiliation

¹ Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180001, India.

PMID: 17950603
DOI: 10.1016/j.bmcl.2007.10.011

Abstract

4-Amino analogues prepared from beta-boswellic acid and 11-keto-beta-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / toxicity*
Apoptosis / drug effects
Apoptosis / genetics
Boswellia* / chemistry
Cell Line, Tumor
DNA Fragmentation / drug effects
Growth Inhibitors / toxicity*
Humans
Triterpenes / chemistry
Triterpenes / toxicity*

Substances

Antineoplastic Agents, Phytogenic
Growth Inhibitors
Triterpenes
boswellic acid