Abstract
Considerable progress has been made in our understanding of the mechanisms underlying regulation of human IgE synthesis. Interleukin-4 induces IgE production specifically, but costimulatory signals provided by T cells are required. Other cytokines modulate interleukin-4-induced IgE synthesis. The roles of T cells and cytokines in regulating IgE switching are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antibody Diversity / genetics
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Gene Expression Regulation
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Genes, Immunoglobulin
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Humans
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Immunoglobulin E / biosynthesis*
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Immunoglobulin E / genetics
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Immunoglobulin Switch Region
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Interleukin-4 / biosynthesis
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Interleukin-4 / physiology*
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T-Lymphocytes / immunology*
Substances
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Interleukin-4
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Immunoglobulin E