Phytochemicals from Echinacea and Hypericum: A Direct Synthesis of Isoligularone

Synth Commun. 2007 Jan;37(8):1251-1257. doi: 10.1080/00397910701215544.

Abstract

Reaction of trienes with α,β-unsaturated aldehydes produces bicyclic products via a tandem Diels-Alder/ene reaction. The adduct from tiglic aldehyde was converted into isoligularone by conversion to a furan followed by benzylic oxidation.