Sentinel lymph node biopsy is a useful diagnostic technique in the management of breast cancer and is widely used and accepted in clinical practice. The results of this technique allow adequate staging with lower associated morbidity. However, at present, there are numerous methodological issues that remain to be resolved in on-going trials and investigations and Consensus Meetings are required to standardize the methodological variations and indications of this procedure. The conclusions of the Consensus Meeting held in Murcia, Spain, organized by The Spanish Society of Mastology and Breast Disease, are reported in this document.