Oral glucose tolerance test: a reliable tool for early detection of glucose abnormalities in patients with acute myocardial infarction in clinical practice: a report on repeated oral glucose tolerance tests from the GAMI study

Diabetes Care. 2008 Jan;31(1):36-8. doi: 10.2337/dc07-1552. Epub 2007 Oct 1.

Abstract

Objective: Previously undetected glucose abnormalities are common in patients with acute myocardial infarction (AMI). We evaluated long-term reliability of early glucometabolic classification of patients with AMI by repeated oral glucose tolerance tests (OGTTs).

Research design and methods: A glucometabolic OGTT-based classification was obtained in 122 patients by measuring capillary whole-blood glucose. The classification was performed on three occasions, before hospital discharge and 3 and 12 months thereafter.

Results: At discharge, 34, 31, and 34% were classified as having normal glucose tolerance, impaired glucose tolerance (IGT), or type 2 diabetes, respectively, and 93% of all patients with type 2 diabetes were still classified with type 2 diabetes (n = 27) or IGT (n = 12) after 12 months. The agreements between the OGTTs at discharge and 3 and 12 months were kappa = 0.35, P < 0.001, and kappa = 0.43, P < 0.001, respectively.

Conclusions: The outcome of an OGTT performed in AMI patients at hospital discharge reliably informs on long-term glucometabolic state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetic Angiopathies / blood
  • Follow-Up Studies
  • Glucose Intolerance / epidemiology
  • Glucose Tolerance Test*
  • Humans
  • Myocardial Infarction / blood*
  • Patient Care Planning

Substances

  • Blood Glucose