CREx: inferring genomic rearrangements based on common intervals

Bioinformatics. 2007 Nov 1;23(21):2957-8. doi: 10.1093/bioinformatics/btm468. Epub 2007 Sep 25.

Abstract

Summary: We present the web-based program CREx for heuristically determining pairwise rearrangement events in unichromosomal genomes. CREx considers transpositions, reverse transpositions, reversals and tandem-duplication-random-loss (TDRL) events. It supports the user in finding parsimonious rearrangement scenarios given a phylogenetic hypothesis. CREx is based on common intervals, which reflect genes that appear consecutively in several of the input gene orders.

Availability: CREx is freely available at http://pacosy.informatik.uni-leipzig.de/crex

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Chromosome Mapping / methods*
  • Computer Graphics
  • Gene Rearrangement / genetics*
  • Sequence Analysis, DNA / methods*
  • Software*
  • User-Computer Interface*