A comparison of the metabolic effects of bovine growth hormone and growth factor from Spirometra mansonoides on rat liver in vivo

J Toxicol Environ Health. 1976 May;1(5):793-806. doi: 10.1080/15287397609529378.

Abstract

The effects of bovine growth hormone(GH) and Spirometra growth factor (SGF) on the in vivo concentrationions of glycolytic and citricacid (TCA) cycle intermediates in rat liver were investigated. The effects of these agents on the mitochondrial and cytoplasmic redox states, liver phosphorylation states, and adenylate kinase activity were also evaluated. The effects of SGF were studied in both normal and hypophysectomized rats,wheras GH effects ere examined only in hypophysectomized rats. Growth homrone(0.25mg/rat) was injected dayily for 9 days...

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenine Nucleotides / metabolism
  • Animals
  • Cestoda*
  • Cestode Infections / metabolism
  • Cytoplasm / metabolism
  • Growth Hormone / pharmacology*
  • Growth Substances / pharmacology*
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • NAD / metabolism
  • Oxidative Phosphorylation / drug effects
  • Pituitary Gland / physiology
  • Rats
  • Sparganum*

Substances

  • Adenine Nucleotides
  • Growth Substances
  • NAD
  • Growth Hormone