Abstract
The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / chemical synthesis*
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Antimalarials / chemistry
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Antimalarials / pharmacology
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Fosfomycin / analogs & derivatives*
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Fosfomycin / chemical synthesis
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Fosfomycin / chemistry
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Fosfomycin / pharmacology
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Hydrogenation
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Molecular Structure
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Nitroso Compounds / chemistry*
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Organophosphonates / chemistry*
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Structure-Activity Relationship
Substances
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Antimalarials
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Nitroso Compounds
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Organophosphonates
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Fosfomycin
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3-(N-acetyl-N-hydroxy)aminopropylphosphonic acid