Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease

J Neurol Sci. 2008 Mar 15;266(1-2):13-9. doi: 10.1016/j.jns.2007.08.022. Epub 2007 Sep 19.

Abstract

To investigate whether fractalkine receptor CX3CR1 polymorphisms that have been associated with rapid progression to AIDS among HIV-1 positive individuals also affects the risk of human T cell lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP), we compared the allele frequencies of V249I and T280M between 233 HAM/TSP patients and 213 HTLV-1 seropositive asymptomatic carriers (HCs). Although the frequency and absolute number of peripheral blood CX3CR1+CD4+T cells were significantly increased in HAM/TSP patients compared to HCs and uninfected controls independent of HTLV-1 trans-activator protein Tax, we could not observe any association between the two polymorphisms and the risk of HAM/TSP in our cohort.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • CD4-Positive T-Lymphocytes / metabolism*
  • CD8-Positive T-Lymphocytes / metabolism
  • CX3C Chemokine Receptor 1
  • Carrier State
  • Deltaretrovirus Antibodies / analysis
  • Flow Cytometry
  • Genotype
  • HIV Infections / genetics
  • Humans
  • Lymphocyte Count
  • Paraparesis, Tropical Spastic / genetics
  • Paraparesis, Tropical Spastic / metabolism*
  • Paraparesis, Tropical Spastic / pathology*
  • Polymorphism, Genetic / genetics
  • Receptors, Chemokine / biosynthesis*
  • Receptors, Chemokine / genetics
  • Spinal Cord / enzymology
  • Spinal Cord / pathology

Substances

  • CX3C Chemokine Receptor 1
  • CX3CR1 protein, human
  • Deltaretrovirus Antibodies
  • Receptors, Chemokine