Unusual dimeric Zn(II)-cytosine complexes: new models of the interaction of Zn(II) with DNA and RNA

J Inorg Biochem. 2008 Feb;102(2):203-8. doi: 10.1016/j.jinorgbio.2007.07.036. Epub 2007 Aug 7.

Abstract

Synthesis and crystal structure of two Zn(II) dimer complexes with 1-methylcytosine (1-MeC) are reported. In complex [Zn(2)Cl(4)(mu-1-MeC-O2,N3)(2)] (1), two 1-MeC ligands are bridging two ZnCl(2) moieties. In [Zn(2)(1-MeC-N3)(4)(mu-SO(4))(2)].2H(2)O (2), the sulfates act as bridging ligands and 1-MeC are linked via N3 to Zn(II) as terminal ligands. Both complexes represent the first examples of Zn(II)-pyrimidine dimers. The potential biological significance of 1 and 2 is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytosine / analogs & derivatives*
  • Cytosine / chemistry
  • DNA / chemistry*
  • Dimerization
  • Ligands
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry*
  • RNA / chemistry*
  • Zinc / chemistry*

Substances

  • Ligands
  • Organometallic Compounds
  • 1-methylcytosine
  • RNA
  • Cytosine
  • DNA
  • Zinc