Abstract
The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Catalysis
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Chromatin Assembly and Disassembly*
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Enzyme Inhibitors
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F-Box Proteins
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Histone Demethylases
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Histones / metabolism*
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Humans
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Jumonji Domain-Containing Histone Demethylases
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Methylation
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Oxidoreductases, N-Demethylating / metabolism*
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Protein Processing, Post-Translational*
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Substrate Specificity
Substances
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Enzyme Inhibitors
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F-Box Proteins
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Histones
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Histone Demethylases
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Jumonji Domain-Containing Histone Demethylases
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KDM2A protein, human
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KDM1A protein, human
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Oxidoreductases, N-Demethylating