Splitting livers - balancing the gain and the pain

Transpl Int. 2008 Mar;21(3):218-22. doi: 10.1111/j.1432-2277.2007.00553.x. Epub 2007 Sep 11.

Abstract

Division of donor livers has allowed effective expansion of the donor pool and has been associated with a reduction in the mortality of children awaiting liver transplantation. However, adult recipients of a split graft tend to have inferior transplant survival, compared with recipients of a whole graft. We have analysed the impact of the splitting programme at a particular centre on the life-years lost or gained in both adult and paediatric recipients. We estimate that at 1 year after transplantation, splitting livers has resulted in a gain of five life-years for the paediatric recipients with a loss of six adult patient years; at 5 years post-transplant, a gain of 25 life-years for the paediatric recipients balances a loss of 30 life-years for adult recipients. While this analysis is based on a number of assumptions, and so the results must be treated with caution, it does give rise to a number of ethical considerations which require open and public debate.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Hepatectomy / methods*
  • Humans
  • Liver Transplantation / methods*
  • Liver Transplantation / mortality
  • Proportional Hazards Models
  • Survival Analysis
  • Tissue and Organ Harvesting / methods*
  • Treatment Failure
  • Waiting Lists