Problems of assessment of life quality of children with benign hematological diseases (hereditary microspheric anemia, thalassemia, idiopathic thrombocytopenic purpura) after laparoscopic cholecystectomy are discussed. The standard SF-36 scale was used before and after endoscopic surgery. It is demonstrated that after reasonable laparoscopic splenectomy almost all parameters of life quality are improved. Improvement of physical parameters argues for small surgical trauma and slight postoperative period after laparoscopic splenectomy.