Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs

Ann Hum Genet. 2008 Jan;72(Pt 1):26-34. doi: 10.1111/j.1469-1809.2007.00393.x. Epub 2007 Sep 5.

Abstract

Retinitis pigmentosa (RP) is a group of retinal dystrophies characterised primarily by rod photoreceptor cell degeneration. Exhibiting great clinical and genetic heterogeneity, RP be inherited as an autosomal dominant (ad) and recessive (ar), X-linked (xl) and digenic disorder. RP25, a locus for arRP, was mapped to chromosome 6p12.1-q14.1 where several retinal dystrophy loci are located. A gene expressed in the retina, FAM46A, mapped within the RP25 locus, and computational data revealed its involvement in retinal signalling pathways. Therefore, we chose to perform molecular evaluation of this gene as a good candidate in arRP families linked to the RP25 interval. A comprehensive bioinformatic and retinal tissue expression characterisation of FAM46A was performed, together with mutation screening of seven RP25 families. Herein we present 4 novel sequence variants, of which one is a novel deletion within a low complexity region close to the initiation codon of FAM46A. Furthermore, we have characterised for the first time a coding tandem variation in the Caucasian population. This study reports on bioinformatic and moleculardata for the FAM46A gene that may give a wider insight into the putative function of this gene and its pathologic relevance to RP25 and other retinal diseases mapping within the 6q chromosomal interval.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • Case-Control Studies
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6
  • Computational Biology / methods
  • DNA Mutational Analysis
  • Family*
  • Gene Frequency
  • Genes, Recessive*
  • Humans
  • Introns
  • Minisatellite Repeats / genetics*
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Retinitis Pigmentosa / genetics*
  • Retinitis Pigmentosa / pathology
  • Sequence Deletion
  • Spain