SLAM-associated protein solves a mystery of autoimmunity

Shigemasa Sawada; Masami Takei; Tetsuyosi Ishiwata; Hidetaka Shiraiwa; Hirotake Inomata; Takamasa Nozaki

doi:10.1196/annals.1398.003

SLAM-associated protein solves a mystery of autoimmunity

Ann N Y Acad Sci. 2007 Aug:1109:19-30. doi: 10.1196/annals.1398.003.

Authors

Shigemasa Sawada¹, Masami Takei, Tetsuyosi Ishiwata, Hidetaka Shiraiwa, Hirotake Inomata, Takamasa Nozaki

Affiliation

¹ Department of Rheumatology and Hematology, Nihon University Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo 197-0072, Japan. sswd98@med.nihon-u.ac.jp

PMID: 17785286
DOI: 10.1196/annals.1398.003

Abstract

SLAM-associated protein (SAP) is essential for viral protection, lifelong immune memory (vaccination), and lifelong autoantibody production. We discuss how SAP is a key player in the development of autoimmune disease.

MeSH terms

Animals
Apoptosis
Arthritis, Rheumatoid / immunology
Arthritis, Rheumatoid / pathology
Autoimmunity / immunology*
Cloning, Molecular
Glomerulonephritis, IGA / genetics
Glomerulonephritis, IGA / immunology
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / immunology*
Lymphocytes / metabolism
Lymphoproliferative Disorders / genetics
Lymphoproliferative Disorders / immunology

Substances

Intracellular Signaling Peptides and Proteins