Pordamacrines A and B, alkaloids from Daphniphyllum macropodum

J Nat Prod. 2007 Sep;70(9):1516-8. doi: 10.1021/np070226g. Epub 2007 Aug 21.

Abstract

The new Daphniphyllum alkaloids, pordamacrines A (1) and B (2), have been isolated from the leaves of Daphniphyllum macropodum, and their structures were elucidated on the basis of interpretation of spectroscopic data and by the single-crystal X-ray diffraction analysis of 2. Pordamacrines A (1) and B (2) exhibited moderate vasorelaxant effects on the rat aorta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Aorta, Thoracic / drug effects
  • Crystallography, X-Ray
  • Japan
  • Male
  • Molecular Conformation
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Wistar
  • Vasodilator Agents / chemistry
  • Vasodilator Agents / isolation & purification*
  • Vasodilator Agents / pharmacology

Substances

  • Alkaloids
  • Vasodilator Agents
  • pordamacrine A
  • pordamacrine B