Characteristic quantities of microvascular structures in CLSM volume datasets

IEEE Trans Med Imaging. 2007 Aug;26(8):1103-14. doi: 10.1109/TMI.2007.900379.

Abstract

A method for fully automated morphological and topological quantification of microvascular structures in confocal laser scanning microscopy (CLSM) volume datasets is presented. Several characteristic morphological and topological quantities are calculated in a series of image-processing steps and can be used to compare single components as well as whole networks of microvascular structures to each other. The effect of the individual image-processing steps is illustrated and characteristic quantities of measured volume datasets are presented and discussed.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Artificial Intelligence
  • Databases, Factual*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Information Storage and Retrieval / methods
  • Microcirculation / cytology*
  • Microscopy, Confocal / methods*
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity