A new cytotoxic cholesterol sulfate from marine sponge Halichondria rugosa

Nat Prod Res. 2007 Sep;21(11):953-8. doi: 10.1080/14786410701371330.

Abstract

A new steroid, 24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol sodium sulfate (1), together with a known steroid, 24xi,25-dimethyl-cholest-5-ene-2beta,3alpha-diol disodium sulfate (2), was isolated from the ethanol extract of marine sponge Halichondria rugosa. Their structures were elucidated on the base of spectroscopic analysis. Both compounds showed cytotoxicity to four human cancer cell lines (BEL-7402, HT-29, SPC-A1 and U-251) with IC(50) values between 6.5 and 23.1 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology*
  • Cholesterol Esters / chemistry
  • Cholesterol Esters / isolation & purification*
  • Cholesterol Esters / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Marine Biology
  • Molecular Structure
  • Porifera

Substances

  • 24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol
  • Antineoplastic Agents
  • Cholesterol Esters
  • cholesteryl sulfate