Recognition of category-related visual stimuli in Parkinson's disease: before and after pharmacological treatment

Neuropsychologia. 2007 Oct 1;45(13):2931-41. doi: 10.1016/j.neuropsychologia.2007.06.002. Epub 2007 Jun 16.

Abstract

Visual-sensory dysfunctions and semantic processing impairments are widely reported in Parkinson's disease (PD) research. The present study investigated the category-specific deficit in object recognition as a function of both the semantic category and spatial frequency content of stimuli. In the first experiment, the role of dopamine in object-recognition processing was assessed by comparing PD drug naïve (PD-DN), PD receiving levodopa treatment (PD-LD), and control subjects. Experiment 2 consisted of a retest session for PD drug naïve subjects after a period of pharmacological treatment. All participants completed an identification task which displayed animals and tools at nine levels of filtering. Each object was revealed in a sequence of frames whereby the object was presented at increasingly less-filtered images up to a complete version of the image. Results indicate an impaired identification pattern for PD-DN subjects solely for animal category stimuli. This differential pharmacological therapy effect was also confirmed at retest (experiment 2). Thus, our data suggest that dopaminergic loss has a specific role in category-specific impairment. Two possible hypotheses are discussed that may account for the defective recognition of semantically different objects in PD.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Analysis of Variance
  • Antiparkinson Agents / therapeutic use*
  • Case-Control Studies
  • Classification
  • Contrast Sensitivity / drug effects
  • Contrast Sensitivity / physiology*
  • Dopamine / physiology
  • Female
  • Form Perception / drug effects*
  • Form Perception / physiology
  • Humans
  • Levodopa / therapeutic use*
  • Male
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology
  • Parkinson Disease / psychology
  • Photic Stimulation
  • Recognition, Psychology / drug effects*
  • Recognition, Psychology / physiology
  • Reference Values
  • Statistics, Nonparametric

Substances

  • Antiparkinson Agents
  • Levodopa
  • Dopamine