A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy

Epilepsia. 2007 Dec;48(12):2357-60. doi: 10.1111/j.1528-1167.2007.01217.x. Epub 2007 Jul 25.

Abstract

Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interval episodes of Total Axis I Disorders and Mood Disorders, indicating a poorer prognosis for these comorbidities in the context of chronic temporal lobe epilepsy.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Chronic Disease
  • Comorbidity
  • Control Groups
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / epidemiology
  • Diagnostic and Statistical Manual of Mental Disorders
  • Epilepsy, Temporal Lobe / diagnosis
  • Epilepsy, Temporal Lobe / epidemiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / epidemiology*
  • Middle Aged
  • Mood Disorders / diagnosis
  • Mood Disorders / epidemiology
  • Odds Ratio
  • Prognosis
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Risk Factors