Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug

Angew Chem Int Ed Engl. 2007;46(34):6469-72. doi: 10.1002/anie.200701270.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Biotin / pharmacology
  • CHO Cells
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives*
  • Camptothecin / pharmacology
  • Cricetinae
  • Cricetulus
  • Enzyme Inhibitors / administration & dosage*
  • Enzyme Inhibitors / pharmacology*
  • Enzyme-Linked Immunosorbent Assay
  • HT29 Cells
  • Humans
  • Irinotecan
  • Prodrugs / administration & dosage*
  • Prodrugs / pharmacology*
  • Shiga Toxin / pharmacology*
  • Shiga Toxins / pharmacology
  • Topoisomerase II Inhibitors*
  • Trihexosylceramides / metabolism

Substances

  • Antineoplastic Agents, Phytogenic
  • Enzyme Inhibitors
  • Prodrugs
  • Shiga Toxins
  • Topoisomerase II Inhibitors
  • Trihexosylceramides
  • stxB toxin
  • Biotin
  • globotriaosylceramide
  • Shiga Toxin
  • Irinotecan
  • Camptothecin