Abstract
Soy isoflavone aglycones (IFAs) have a wide range of biological actions. We investigated in this study the effect of IFAs on myeloid cells. The cell surface expression of both CD80 and CD86 was up-regulated by treating myeloid cells with IFAs in vitro and in vivo. The findings suggest that IFAs could modulate the myeloid cell function.
MeSH terms
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Animals
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B7-1 Antigen / biosynthesis
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B7-1 Antigen / genetics*
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B7-2 Antigen / biosynthesis
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B7-2 Antigen / genetics*
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Cell Line
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Dose-Response Relationship, Drug
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Female
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Gene Expression Regulation / physiology*
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Isoflavones / physiology*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred DBA
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Myeloid Cells / metabolism*
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beta-Glucans
Substances
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B7-1 Antigen
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B7-2 Antigen
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Isoflavones
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beta-Glucans
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soy isoflavone aglycone