Analysis of antidiuretic effect of arginine-vasotocin and its analogs in primates

Bull Exp Biol Med. 2006 Dec;142(6):714-6. doi: 10.1007/s10517-006-0459-7.
[Article in English, Russian]

Abstract

Intramuscular injection of synthetic analogs of arginine-vasotocin to monkeys after 3% water loading caused antidiuretic reaction, manifesting by reabsorption of osmotically free water and paralleled by significant changes in excretion of sodium or potassium ions. It is shown that synthetic analogs can be more effective and selective than natural agonists.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidiuretic Agents / pharmacology*
  • Arginine Vasopressin / analogs & derivatives*
  • Arginine Vasopressin / pharmacology
  • Diuresis / drug effects*
  • Diuretics / pharmacology
  • Ions / metabolism
  • Macaca mulatta / physiology*
  • Male
  • Osmolar Concentration
  • Potassium / metabolism
  • Sodium / metabolism
  • Vasotocin / pharmacology*

Substances

  • Antidiuretic Agents
  • Diuretics
  • Ions
  • Arginine Vasopressin
  • Sodium
  • Potassium
  • Vasotocin