Abstract
We determined the levels of adenovirus 5 (Ad5) neutralizing antibodies in children in India less than 2 years of age. The results clearly show an age-dependent increase in Ad5-specific immunity, with 7- to 12-month-old children having the lowest levels of Ad5 immunity. This opens up the scope for the use of recombinant Ad5-based vaccines in this age group.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenovirus Infections, Human / epidemiology*
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Adenovirus Infections, Human / immunology
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Adenovirus Infections, Human / virology
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Adenoviruses, Human / classification
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Adenoviruses, Human / genetics
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Adenoviruses, Human / immunology*
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Age Factors
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Antibodies, Viral / blood*
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Child, Preschool
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Enzyme-Linked Immunosorbent Assay
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Humans
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India / epidemiology
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Infant
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Infant, Newborn
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Neutralization Tests
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Serotyping
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Vaccines, Synthetic
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Viral Vaccines
Substances
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Antibodies, Viral
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Vaccines, Synthetic
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Viral Vaccines