Abstract
Using the rabbit endocarditis model, we compared the activity of a new broad-spectrum cephalosporin, ceftaroline, with those of linezolid and vancomycin against methicillin-resistant Staphylococcus aureus. After a 4-day treatment, ceftaroline exhibited superior bactericidal in vivo activity against resistant S. aureus strains and appeared to be the most effective drug against a heterogeneous glycopeptide-intermediate S. aureus strain.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology
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Acetamides / therapeutic use*
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Animals
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Area Under Curve
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Ceftaroline
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Cephalosporins / pharmacology
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Cephalosporins / therapeutic use*
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Chromatography, High Pressure Liquid
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Colony Count, Microbial
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology*
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Immunoenzyme Techniques
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Linezolid
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Methicillin Resistance / drug effects*
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Microbial Sensitivity Tests
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Oxazolidinones / pharmacology
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Oxazolidinones / therapeutic use*
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Rabbits
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / drug effects*
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Treatment Outcome
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Vancomycin / pharmacology
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Vancomycin / therapeutic use*
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Vancomycin Resistance / drug effects*
Substances
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Acetamides
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Anti-Bacterial Agents
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Cephalosporins
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Oxazolidinones
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Vancomycin
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Linezolid